Bolus dose of hydroxycitric acid with glycerol
AssigneeGlykon Technologies Group, LLC
InventorsDallas L. CLOUATRE, Daniel E. CLOUATRE, Brad J. DOUGLASS
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Abstract
A method of delivering a daily dose of hydroxycitric acid in the form of a salt as a single bolus that is as effective or more so than the same amount of active delivered via two or three administrations (b.i.d. or t.i.d.) using current delivery modalities. The method reduces the rate of occurrence of common adverse events with hydroxycitric acid salts, and reduces the occurrence of reverse effects on diets high in fat and/or alcohol. The method improves the uptake of the active compound thereby reducing the dose required.
Claims24
-20. (canceled)
A liquid formulation prepared by a process comprising the steps of:
- mixing glycerol in purified water wherein the glycerol is present in an amount of about 1 to 3 parts by volume and the purified water is present in an amount of about 3 to 1 parts by volume to create a glycerol and purified water solution;
- and
- dissolving HCA in the glycerol and purified water solution to obtain an HCA concentration ranging from about 1.1 to 1.7 molar dosage.
A sealed dosage container, comprising:
- an aqueous solution of a hydroxycitrate salt (HCA) in combination with glycerol, wherein the hydoxycitrate salt is present in the sealed container in amount of 3.0 g to 4.5 g ±20%, and the glycerol is present in the container in an amount in a range of from 1.0 g to 4.0 g ±20%, and
- wherein the liquid sealed dosage is prepared by a process comprising the steps of:
- mixing glycerol purified water wherein the glycerol is present in an amount of about 1 to 3 parts by volume and the purified water is present in an amount of about 3 to 1 parts by volume to create a glycerol and purified water solution;
- and
- dissolving HCA in the glycerol and purified water solution to obtain an HCA concentration ranging from about 1.1 to 1.7 molar dosage.
A dosage unit, comprising:
- a contained holding a solution of glycerol and water wherein the glycerol is present in an amount of about 1 to 3 parts by volume and the water is present in an amount of about 3 to 1 parts by volume to create the solution having dissolved therein hydroxycitrate salt (HCA) at a concentration ranging from about 1.1 to 1.7 molar dosage, wherein the solution is substantially free of lactones of the HCA.
Dependencies are inferred from the claim text.