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AssigneeMurray and Poole Enterprises Ltd
InventorMark Nidorf
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A method for the treatment or prevention of a cardiovascular event in a subject with atherosclerotic vascular disease comprising the step of: b) administering a therapeutically effective amount of a compound of formula (I), a known colchicine derivative and/or a salt thereof wherein: R1, R2, R3, R4, R9, R10, R11 and R12 independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-6 cycloalkyl, halogen, C1-4 haloalkyl, nitro, amino, C2-4 acylamino, C1-4 alkyl or dialkylamino, hydroxyl, C1-4 alkoxy, C1-4 alkylthio, a group of the formula —SO2N(Rx)2 or SO2Rx where Rx is C1-4 alkyl, C1-4 acyloxy, or optionally substituted phenyl, optionally substituted phenoxy; R7 and R8 independently represent hydrogen, C1-4 alkyl or C1-4 acyl; and R5′, R5″, R6′ and R6″ independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-6 cycloalkyl, halogen, C1-4 haloalkyl, nitro, amino, C2-4 acylamino, hydroxyl, C1-4 alkoxy or C1-4 alkylthio a group of the formula —SO2N(Rx)2 or SO2Rx where Rx is C1-4 alkyl, C1-4 acyloxy, or optionally substituted phenyl.
1-16. (canceled)
A method for treating and/or reducing the risk of a cardiovascular event in a subject in need thereof, that comprises administering to the subject a therapeutically effective amount of a liquid solution comprising (i) colchicine, (ii) a salt of (i), or any combination of (i)-(ii),
A method for treating and/or reducing the risk of inflammation in a subject having, or having a previous history of, atherosclerotic vascular disease, that comprises administering to the subject a liquid solution comprising (i) colchicine, (ii) a salt of (i), or any combination of (i)-(ii),
A method for reducing or reducing the risk of cholesterol crystal induced inflammation within an atherosclerotic plaque in a subject in need thereof, that comprises administering to the subject a liquid solution comprising (i) colchicine, (ii) a salt of (i), or any combination of (i)-(ii),
Dependencies are inferred from the claim text.