Use of 2-hydroxybenzylamine in the treatment and prevention of pulmonary hypertension
AssigneeVanderbilt University
InventorsJoshua P. Fessel, L. Jackson Roberts, II, James West
Life of this patent
Estimating the term…
Abstract
Compounds for use in methods of treating, preventing, or ameliorating pulmonary hypertension; reducing glutamine metabolism in a patient in need thereof, and/or increasing SIRT3 activity in a patient in need thereof.
Claims18
A method of treating, preventing, or ameliorating pulmonary hypertension, comprising administrating to a patient in need thereof a compound of the following formula:
- wherein:
- R is N or C—R5;
- R2 is independently H, substituted or unsubstituted alkyl, alkoxy, alkyl-alkoxy;
- R3 is H, substituted or unsubstituted alkyl, halogen, alkoxy, hydroxyl, nitro;
- R4 is H, substituted or unsubstituted alkyl, carboxyl, carboxylic acid, alkyl-carboxylic acid;
- R5 is H, substituted or unsubstituted alkyl;
- and pharmaceutically acceptable salts thereof.
A method of reducing glutamine metabolism in a patient in need thereof, comprising administrating to a patient in need thereof a compound of the following formula:
- wherein:
- R is N or C—R5;
- R2 is independently H, substituted or unsubstituted alkyl, alkoxy, alkyl-alkoxy;
- R3 is H, substituted or unsubstituted alkyl, halogen, alkoxy, hydroxyl, nitro;
- R4 is H, substituted or unsubstituted alkyl, carboxyl, carboxylic acid, alkyl-carboxylic acid;
- R5 is H, substituted or unsubstituted alkyl;
- and pharmaceutically acceptable salts thereof.
A method of increasing SIRT3 activity in a patient in need thereof, comprising administrating to a patient in need thereof a compound of the following formula:
- wherein:
- R is N or C—R5;
- R2 is independently H, substituted or unsubstituted alkyl, alkoxy, alkyl-alkoxy;
- R3 is H, substituted or unsubstituted alkyl, halogen, alkoxy, hydroxyl, nitro;
- R4 is H, substituted or unsubstituted alkyl, carboxyl, carboxylic acid, alkyl-carboxylic acid;
- R5 is H, substituted or unsubstituted alkyl;
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.