Porous polymer microspheres for preventing or treating soft tissue diseases and method for manufacturing the same
AssigneesKorea University Research and Business Foundation, Ortho Heal Co., Ltd.
InventorsHae-Ryong SONG, Jae Young LEE, Sungeun KIM, Hak Jun KIM, Young-Pil YUN
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Abstract
Disclosed are porous polymer microspheres for preventing or treating soft tissue diseases including a biodegradable polymer scaffold having a three-dimensional network structure in which pores having a size of 5 to 100 μm are connected to one another, and a drug for treating soft tissue diseases incorporated in the network structure of the biodegradable polymer scaffold.
Claims23
Porous polymer microspheres for preventing or treating soft tissue diseases comprising:
- a biodegradable polymer scaffold having a three-dimensional network structure in which pores having a size of 5 to 100 μm are connected to one another;
- and
- a drug for treating soft tissue diseases incorporated in the network structure of the biodegradable polymer scaffold.
A method for manufacturing porous polymer microspheres for preventing or treating soft tissue diseases comprising:
- 1) dissolving a biocompatible polymer and a drug for treating soft tissue diseases in an organic solvent to prepare a polymer solution;
- 2) homogenizing the polymer solution and an aqueous gelatin solution to prepare an emulsion;
- 3) pouring the emulsion as a discontinuous phase and a polyvinyl alcohol solution as a continuous phase into a fluidic device to produce polymer microspheres including the biocompatible polymer, the drug and gelatin;
- and
- 4) stirring the polymer microspheres in 38-50° C. water to release the gelatin from the polymer microspheres.
Dependencies are inferred from the claim text.