Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
AssigneeMannKind Corporation
InventorsBryan R. Wilson, Marshall Grant
Life of this patent
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Abstract
Methods are provided for drying a particle. Specifically, there is provided a spray-dried diketopiperazine-insulin particle formulation having improved aerodynamic performance and in which the active agent is more stabile and efficiently delivered as compared to that of the lyophilized diketopiperazine-insulin formulation. The dry powders have utility as pharmaceutical formulations for pulmonary delivery.
Claims18
An inhalable dry powder with an improved pharmaceutic property comprising microparticles of a diketopiperazine combined with an active agent wherein the pharmaceutic property are improved by increasing the density of powder, increasing the aerodynamic performance of powder, or improving the stability of the active agent and optionally, one or more pharmaceutically acceptable carriers.
The inhalable dry powder of claim 20, wherein the tapped density is from 0.25 to 0.30 g/cc.
The inhalable dry powder of claim 20, wherein the bulk density is from 0.15 to 0.20 g/cc.
Dependencies are inferred from the claim text.