Implants with controlled drug delivery features and methods of using same
AssigneeDose Medical Corporation
InventorsDavid S. Haffner, Thomas W. Burns, Harold A. Heitzmann, Kenneth M. Curry
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Abstract
Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.
Claims33
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A drug delivery ocular implant comprising:
- an outer shell having a first end and a second closed end, the first end being at least partially open, the outer shell being shaped to define an interior cavity;
- at least a first drug positioned within the interior cavity;
- an elastic membrane permeable or semi-permeable to the at least a first drug, the membrane positioned at the first end of the outer shell and mechanically affixed to the outer shell to form a gasket to close the first end;
- and
- a retention protrusion on the second closed end of the outer shell, wherein the retention protrusion is configured to anchor the ocular implant at a target tissue site in an eye.
A drug delivery ocular implant comprising:
- an outer shell shaped to define an interior space, the outer shell having a sidewall, one closed distal end, and one proximal end, the proximal end being at least partially open;
- at least a first drug contained within the interior space;
- a membrane mechanically affixed to and sealing the proximal end, the membrane controlling flow of the drug out of the implant;
- and
- an anchor on the closed distal end.
Dependencies are inferred from the claim text.