Variable rate prosthesis delivery system providing prosthesis alterations

A method of delivering a prosthesis to a treatment site within the vasculature of a subject using a graft delivery device comprising at least an outer sheath, a pusher shaft, and a central shaft, the method comprising:

• delivering a graft carrying tip of the graft delivery device to the treatment site;
• retracting an outer sheath of the graft delivery device to expose the graft;
• simultaneous to retracting the outer sheath, advancing a pusher shaft of the graft delivery device, a distal end of the pusher shaft contacting the graft to advance the graft distally along the central shaft;
• and
• retracting the outer sheath of the graft delivery device to expose the graft while maintaining a position of the pusher shaft.

A prosthesis delivery system comprising:

• a prosthesis configured for delivery to vasculature of a subject;
• a housing;
• an outer sheath including a proximal portion mechanically coupled to a sheath anchor within the housing;
• a pusher shaft having a distal portion disposed inside of the outer sheath and a proximal portion mechanically coupled to a pusher shaft anchor within the housing;
• a central shaft having a proximal portion and a distal portion disposed inside of the pusher shaft, the graft being mounted on the distal portion of the central shaft;
• a first deployment assembly located exterior to the housing and configured to simultaneously advance the outer sheath and the pusher shaft in opposing axial directions;
• and
• a second deployment assembly located exterior to the housing configured to retract the outer sheath while maintaining the pusher shaft stationary relative to the housing.