Systems and Methods for Producing Gastrointestinal Tissues

A method, comprising the steps of:

• resecting a portion of a tubular organ in a subject, the resection step producing a resected organ portion, the resected organ portion remaining in the subject;
• implanting a synthetic scaffold at the site of resection, the synthetic scaffold including an outer polymeric surface and a cellularized sheath layer overlying at least a portion of the outer polymeric surface;
• maintaining the synthetic scaffold at the resection site for a period of time sufficient to achieve guided tissue growth along the synthetic scaffold, the guided tissue growth derived from and in contact with the tissue present in the resected organ portion remaining in the subject;
• and
• after achieving guided tissue growth, removing the synthetic scaffold from the implantation site, the removing step occurring in a manner such that the guided tissue growth remains in the contact with the resected portion of the tubular organ remaining in the subject.