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US 2019/0300485 A1Published application
Continuous flow carboxylation reaction
AssigneeSarcode Bioscience Inc.
InventorsScott Tweedie, Sripathy Venkatraman, James Zeller
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Abstract
The present invention is related to a two-step carboxylation reaction of an aryl group using continuous flow reaction conditions. This process permits large scale synthesis of useful reaction products in high yield.
Claims11
A process of preparing a compound of Formula I:
- comprising:
- reacting a compound of Formula II:
- with n-BuLi and TMEDA at −78° C. to afford a compound of Formula III:
- quenching said compound of Formula III with gaseous carbon dioxide to afford a compound of Formula IV:
- and
- treating said compound of Formula IV with HCl to afford the compound of Formula I, wherein said method is performed using continuous flow reaction conditions.
3 more elements
Dependencies are inferred from the claim text.