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US 2019/0295720 A1Published application
Immune cell signatures
AssigneeNantOmics, LLC
InventorChristopher W. SZETO
Life of this patent
Estimating the term…
Abstract
An immune gene expression signature is associated with clinical features in tumor samples and can be used to predict the immunological state of a tumor and/or sensitivity of the tumor to immune therapy.
Claims20
A method of characterizing a tumor, comprising:
- quantifying or obtaining expression levels for a plurality of distinct genes, wherein the distinct genes are associated with respective distinct types of immune cells;
- determining over-expression or under-expression for each of the distinct genes relative to respective reference ranges, wherein the reference ranges are specific for a specific tumor type;
- and
- using the over-expression and/or under-expression of each of the distinct genes to infer activity and/or infiltration by the immune cells in the tumor.
1 more element
A method of identifying a patient for immune therapy of a tumor, comprising:
- quantifying or obtaining expression levels for a plurality of distinct genes, wherein the distinct genes are associated with respective distinct types of immune cells;
- determining over-expression or under-expression for each of the distinct genes relative to respective reference ranges, wherein the reference ranges are specific for a specific tumor type;
- using the over-expression and/or under-expression of each of the distinct genes to infer activity and/or infiltration by the immune cells in the tumor;
- and
- using the inferred activity to predict an increased likelihood of positive treatment outcome where the inferred activity and/or infiltration of distinct immune cells in the tumor is increased relative to the respective reference ranges;
- and
- identifying the patient for immune therapy upon prediction of the increased likelihood.
4 more elements
Dependencies are inferred from the claim text.