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AssigneeBeth Israel Deaconess Medical Center, Inc.
InventorsIonita C. Ghiran, Nathan Shapiro, Anish V. Sharda, Edward J. Felton
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Methods and apparatus for detecting cell-bound and soluble antigens in a biological sample are described. The method comprises forming complexes of at least one antibody-coated bead and at least one antigen in a solution, placing the solution in a magnetic field such that the formed complexes levitate in the solution at a particular height, and determining at least one characteristic of the antigen in the complexes based, at least in part, on an image of the complexes showing the magnetic levitation height.
A device for identifying antigens in a biological sample comprising cells using magnetic levitation, the device comprising:
The device of any of the preceding claims, wherein the cells are red blood cells and the antigens are red cell-bound antigens.
The device of any of the preceding claims, wherein the cells are white blood cells and the antigens are eosinophil antigens and/or CD8(+) T-cell-specific antigens.
The device of any of the preceding claims, wherein the container comprises a capillary tube.
The device of any of the preceding claims, wherein each of the magnets in the pair of magnets is a permanent magnet.
The device of any of the preceding claims, wherein the surface field of each of the magnets in the pair of magnets is approximately 0.375 Tesla.
A method of detecting antigens in a biological sample, the method comprising:
A portable point of care (POC) device configured to perform magnetic levitation, the portable POC device comprising:
Dependencies are inferred from the claim text.