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US 2019/0292509 A1Published application
Airlift perfusion bioreactor for the culture of cells
AssigneeKeck Graduate Institute of Applied Life Sciences
InventorCorinna Eleni Doris
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Abstract
An airlift bioreactor for perfusion cell culture comprises a single- or multi-tiered riser for working volume scale-up, an internal inclined gravity settler for cell retention, an outlet port for cell-free spent culture medium removal, and an inlet port for fresh medium addition.
Claims20
A bioreactor apparatus, comprising:
- a cell culture zone comprising a riser section and a downcomer section;
- a settling zone comprising an inclined gravity settler in fluid communication with the downcomer section, the inclined gravity settler being partitioned from the riser section;
- a gas injection inlet to the riser section;
- a liquid inlet to the cell culture zone;
- and
- a liquid outlet on the inclined gravity settler.
3 more elements
Dependencies are inferred from the claim text.