Loading patent…
AssigneesCommissariat A L'energie Atomique Et Aux Energies Alternatives, Universite Grenoble Alpes, Centre National De La Recherche Scientifique
InventorsMartin Blackledge, Marlène Ringkjobing-Jensen, Sigrid Milles, Robertus Ruigrok, Guy Schoehn, Guillaume Communie
Estimating the term…
Embodiments of the disclosure relate to the domain of virology of Paramyxoviruses. The disclosure concerns a method for producing self-assembling paramyxoviral particles and a method for identifying a compound able to inhibit the replication or the transcription of a Paramyxovirus. The disclosure also pertains to the nucleocapsid-like particles obtainable by the method of the invention and their use for biotechnological and pharmaceutical applications.
A method for producing self-assembling paramyxoviral nucleocapsid-like particles comprising the steps of:
A nucleocapsid-like viral particle derived from a Paramyxovirus comprising only one specific RNA of interest.
A method for identifying a compound able to inhibit the replication or transcription of a Paramyxovirus, wherein such compound is identified by its ability to abrogate the assembly of the NC-like particles.
A method for identifying a compound able to inhibit the replication or transcription of a Paramyxovirus comprising the steps of:
A purified NºP complex comprising recombinant N and P peptides, wherein the N peptide comprises or consists of at least NCORE domain including a CTD arm and an NTD arm, and the P peptide comprises or consists of at least an N-binding domain, said NºP complex containing no RNA.
Dependencies are inferred from the claim text.