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US 2019/0292206 A1Published application
Gadolinium complex, method for synthesis of the gadolinium complex, and mri contrast agent including the gadolinium complex
AssigneeKyungpook National University Industry-Academic Cooperation Foundation
InventorYong Min CHANG
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Abstract
Disclosed are a gadolinium complex with a high relaxibity at a high magnetic field, a method for synthesizing the complex, and an MRI contrast agent containing the gadolinium complex. The gadolinium complex may be expressed as a Chemical Formula 1:
Claims17
A gadolinium complex expressed as a following Chemical Formula 1:
- wherein the linker represents *—(CH2)n-A-*,
- wherein n indicates an integer of 0 to 5,
- wherein A represents *—COO—*, *—CO—*, *—CONH—*, *—O—* or *—C5N(RaRb)—*,
- wherein R represents a hydrogen atom, a hydroxyl group, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, an aryl group having 5 to 20 carbon atoms, a heteroaryl group having 4 to 20 carbon atoms or *—NR1R2,
- wherein each of Ra, Rb, R1 and R2 independently represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms.
2 more elements
A MRI (magnetic resonance image) contrast agent containing a gadolinium complex expressed as a following Chemical Formula 1:
- wherein the linker represents *—(CH2)n-A-*,
- wherein n indicates an integer of 0 to 5,
- wherein A represents *—COO—*, *—CO—*, *—CONH—*, *—O—* or *—C5N(RaRb)—*,
- wherein R represents a hydrogen atom, a hydroxyl group, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, an aryl group having 5 to 20 carbon atoms, a heteroaryl group having 4 to 20 carbon atoms or *—NR1R2,
- wherein each of Ra, Rb, R1 and R2 independently represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms.
2 more elements
A method for producing a gadolinium complex, the method including:
- synthesizing a chalcone-based compound represented by a following Chemical Formula 1-1;
- synthesizing a compound represented by a following Chemical Formula 1-2 using the compound represented by the Chemical Formula 1-1;
- producing a ligand represented by a following Chemical Formula 1-3 using the compound represented by the Chemical Formula 1-2;
- and
- synthesizing a gadolinium complex represented by a following Chemical Formula 1 using the ligand represented by the Chemical Formula 1-3 and gadolinium chloride hexahydrate:
- wherein in the Chemical Formula 1-1, X represents a halogen atom,
- wherein the linker in each of the Chemical Formulas 1-2 and 1-3 and Chemical Formula 1 represents *—(CH2)n-A-*,
- wherein in the Chemical Formula 1-1 and in the linker of each of the Chemical Formulas 1-2, and 1-3 and Chemical Formula 1, n represents an integer of 0 to 5,
- wherein A represents *—COO—*, *—CO—*, *—CONH—*, *—O—* or *—C5N(RaRb)—*,
- wherein R represents a hydrogen atom, a hydroxyl group, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, an aryl group having 5 to 20 carbon atoms, a heteroaryl group having 4 to 20 carbon atoms or *—NR1R2,
- wherein each of Ra, Rb, R1 and R2 independently represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms.
8 more elements
Dependencies are inferred from the claim text.