An improved process for the preparation of dasatinib polymorph
AssigneeNatco Pharma Limited
InventorsDurga Prasad KONAKANCHI, Buchappa GONGALLA, Uma Naresh Babu KOTRA, Srinivasulu SAKKANI, Dharmender RAGIDI, Kotayyababu SIKHA, Venkaiah Chowdary NANNAPANENI
Life of this patent
Estimating the term…
Abstract
The present invention is related to an improved process for the preparation of dasatinib anhydrous crystalline Neat form N-6 with high purity and high yield. The present invention also relates to purification of dasatinib crystalline Neat form N-6.
Claims4
A process for the preparation of dasatinib anhydrous crystalline Neat form N-6 comprising the steps of:
- a) reacting N-(2-chloro-6-methyl-phenyl)-2-[(6-chloro-2-methyl-pyrimidin-4-yl) amino]thiazole-5-carboxamide with N-2-hydroxy ethyl piperazine in presence of C3-C5 alcohol,
- b) adding the methanol to the reaction mass,
- c) isolating the dasatinib crystalline Neat form N-6,
- d) optionally purifying dasatinib crystalline Neat form N-6 using methanol and toluene.
A process for the preparation of dasatinib anhydrous crystalline Neat form N-6 comprising the steps of:
- a) reacting N-(2-chloro-6-methyl-phenyl)-2-[(6-chloro-2-methyl-pyrimidin-4-yl) amino]thiazole-5-carboxamide with N-2-hydroxy ethyl piperazine in presence of 1-propanol,
- b) adding the methanol to the reaction mass,
- c) isolating the dasatinib crystalline Neat form N-6,
- d) optionally purifying dasatinib crystalline Neat form N-6 using methanol and toluene.
A process for the preparation of dasatinib anhydrous crystalline Neat form N-6 comprising the steps of:
- a) reacting N-(2-chloro-6-methyl-phenyl)-2-[(6-chloro-2-methyl-pyrimidin-4-yl) amino]thiazole-5-carboxamide with N-2-hydroxy ethyl piperazine in presence of 1-pentanol,
- b) adding the methanol to the reaction mass,
- c) isolating the dasatinib crystalline Neat form N-6,
- d) optionally purifying dasatinib crystalline Neat form N-6 using methanol and toluene.
Dependencies are inferred from the claim text.