Protein polymer fusions for subcutaneous delivery of small molecules
OwnerJohn Andrew MACKAY, Jugal P. DHANDHUKIA +2inventors
InventorsJohn Andrew MACKAY, Jugal P. DHANDHUKIA, Santosh PEDDI, S. Kenny ROBERTS
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Abstract
Provided herein are second generation FKBP-ELP drug carriers having physicochemical properties for enhanced systemic circulation and methods for their use.
Claims26
An agent comprising an elastin-like peptide (ELP) component, a therapeutic agent and a N-terminus ligand and a C-terminus ligand conjugated to the N-terminus and C-terminus of the ELP, each ligand selected to target a receptor of the therapeutic agent, the N-terminus and the C-terminus ligand being the same or different from each other.
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An isolated polynucleotide encoding an elastin-like peptide (ELP) component that forms a stable nanoparticle above the transition temperature of the ELP and an N-terminus ligand and a C-terminus ligand, wherein each ligand is selected to target a receptor of a therapeutic agent, wherein the N-terminus and the C-terminus ligand may be the same or different from each other.
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Dependencies are inferred from the claim text.