Lipidic furan, pyrrole, and thiophene compounds for use in the treatment of atrophic vaginitis
AssigneeAvoscience, LLC
InventorRichard Huber
Life of this patent
Estimating the term…
Abstract
Provided herein are lipidic furan, pyrrole, and thiophene compounds, compositions, and methods using such compounds and compositions for the treatment of atrophic vaginitis. Specifically, the invention includes administering an effective amount of a compound of Formula I, I′, or I″, or a pharmaceutically acceptable composition, salt, isotopic analog, prodrug, or combination thereof, to a subject suffering from atrophic vaginitis.
Claims21
A compound of Formula I(ap)
A compound of Formula I(aq)
A method for the treatment of atrophic vaginitis in a host, comprising administering an effective amount of a compound of Formula I, I′, or I″ to a host in need thereof:
- wherein;
- each Z is independently O, S or NR5;
- wherein R1, R2, R3 and R4, are the same or different, separately represent a hydrogen atom, a C1-C35 alkyl radical;
- a C1-C35 alkenyl radical;
- or a C1-C35 alkynyl radical;
- said alkyl, alkenyl and alkynyl radicals optionally substituted by one or more halogens and/or by one or more functions chosen from the group consisting of epoxy, hydroxyl (—OH), thiol (—SH), ether (OR5), primary amine (—NH2), secondary amine (—NHR5), tertiary amine (—NR5R6), aldehyde (—CHO), ketone (—COR5), acetyl (˜O—CO—R5) functions wherein R5 and R6 separately represent a hydrogen atom, a C1-C35 alkyl radical, a C1-C35 alkenyl radical, or a C1-C35 alkynyl radical.
Dependencies are inferred from the claim text.