Method for augmenting vision in persons suffering from photoreceptor cell degeneration
AssigneeThe General Hospital Corporation
InventorRichard H. MASLAND
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Abstract
The invention provides compositions and methods of treating subjects afflicted with a photoreceptor disorder. Methods for treating a subject suffering from a disorder characterized by photoreceptor cell degeneration are provided, wherein a gene encoding a photosensitive protein is introduced into a retinal cell of a subject. In one aspect of the invention, the retinal cells which receive the photosensitive protein include non-photoreceptor cells such as horizontal cells, amacrine cells, bipolar cells, and ganglion cells.
Claims18
A method of restoring vision in a subject suffering from a disorder characterized by photoreceptor cell degeneration, comprising introducing into a retinal cell of the subject a gene encoding a photosensitive protein, thereby restoring vision in the subject.
A method for improving the eyesight of a subject suffering from a photoreceptor cell degeneration disorder, the method comprising introducing a gene encoding a photosensitive protein into a retinal cell of the subject, thereby improving eyesight of the subject.
-16. (canceled)
A method of converting a non-photoreceptor neuron into a photoreceptor neuron, comprising inserting a gene encoding a photosensitive protein into a non-photoreceptor cell, thereby generating a photoreceptor neuron.
Dependencies are inferred from the claim text.