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US 2019/0244109 A1Published application
Dna-based digital information storage
AssigneeTwist Bioscience Corporation
InventorsBrian Wayne BRAMLETT, Bill James PECK
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Abstract
Provided herein are compositions, devices, systems and methods for generation and use of biomolecule-based information for storage. Further provided are devices comprising addressable electrodes controlling polynucleotide synthesis (deprotection, extension, or cleavage, etc.) The compositions, devices, systems and methods described herein provide improved storage, density, and retrieval of biomolecule-based information.
Claims26
A device comprising:
- a solid support, wherein the solid support comprises a plurality of wells, wherein each of the wells comprises an addressable locus comprising:
- a synthesis surface located in a bottom region of each of the wells;
- a bottom electrode in addressable communication with the synthesis surface;
- and
- at least one sidewall electrode located on a sidewall of each of the wells, wherein the at least one sidewall electrode is 50 nm to 200 nm from the bottom region.
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A device for storing nucleic acid-based digital information, comprising:
- a solid support, wherein the solid support comprises a plurality of wells, wherein each of the wells comprises an addressable locus comprising:
- a synthesis surface located in a bottom region of each of the wells;
- a bottom electrode in addressable communication with the synthesis surface;
- and
- at least one sidewall electrode located on a sidewall of each of the wells, wherein the synthesis surface at each addressable locus comprises at least one polynucleotide extending from the synthesis surface, wherein the polynucleotides comprising different sequences on the solid support are present at a density of at least 100×106 polynucleotides per cm2 and wherein at least some of the polynucleotides encode for digital information.
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Dependencies are inferred from the claim text.