Systems and methods for providing dynamic, individualized digital therapeutics for cancer prevention, detection, treatment, and survivorship

A method comprising:

• managing, by a server system, generation of individualized application content providing digital therapeutics interventions tailored individually for each of a plurality of users who are cancer patients or cancer survivors,
• wherein the server system is configured to generate the individualized application content using different combinations of programs from a plurality of digital therapeutics programs, each of the digital therapeutics programs having multiple discrete program states, at least some of the different program states each specifying different levels of user interaction or different levels of intensity of the corresponding digital therapeutics program when the digital therapeutics program is active for a user,
• wherein each particular program state has a different, predetermined set of corresponding program state data that is used by the digital therapeutics program for multiple users, the program state data comprising program content and rules that control interaction of the digital therapeutics program with the multiple users when the particular program state is assigned for any of the multiple users,
• wherein the server system is configured to (i) set the program states of the digital therapeutics programs for individual users based at least in part on the program states of the other digital therapeutics programs and (ii) operate the digital therapeutics programs independent of the program states of the other programs, such that operation of individual digital therapeutics programs is not blocked by the operation of or delays of the other digital therapeutics programs;
• communicating, by server system, individualized application content over a network to (i) a first device associated with a first user that is a cancer patient or cancer survivor, (ii) a second device associated with a caregiver of the first user, and (iii) a third device associated with a friend or family member of the first user, wherein the server system generates the individualized application content using a plurality of digital therapeutics programs that each correspond to a different aspect of cancer treatment and cancer survivorship, the server system being configured to generate the individualized application content using combinations of the digital therapeutics programs and user-specific sets of program states of the digital therapeutics programs for the first user
• automatically varying, by the server system, the user-specific set of program states of the plurality of digital therapeutics programs to assign updated user-specific set of program states for the first user and alter the digital therapeutics interventions provided to the first user, wherein the server system enforces interdependence of the digital therapeutics programs by altering the program states for the first user for at least some of the digital therapeutics programs based on stored data indicating the program states of one or more of the other digital therapeutics programs for the first user;
• generating, by the server system, second individualized application content for the first user by applying, for each of multiple of the digital therapeutics programs that are active for the first user, the set of rules corresponding to the updated program state for the digital therapeutics program;
• and
• distributing, by the server system and to the first device, the second individualized application content generated for the first user according to the updated user-specific set of program states for the first user.

One or more non-transitory computer-readable media storing instructions that, when executed by one or more computers of a server system, cause the one or more computers to perform operations comprising:

• providing personalized digital therapeutics by communicating, by the server system, individualized application content over a network to (i) a first device associated with a first user that is a cancer patient or cancer survivor, (ii) a second device associated with a caregiver of the first user, and (iii) a third device associated with a friend or family member of the first user, wherein the server system generates the individualized application content using a plurality of digital therapeutics programs that each correspond to a different aspect of cancer treatment and cancer survivorship, the server system being configured to generate the individualized application content using combinations of the digital therapeutics programs and user-specific sets of program states of the digital therapeutics programs for the first user, wherein the server system is configured to generate the individualized application content using different combinations of programs from the plurality of digital therapeutics programs, each of the digital therapeutics programs having multiple predetermined program states, at least some of the different program states each specifying different levels of interaction or different levels of intensity of the corresponding digital therapeutics program when the digital therapeutics program is active for a user, each of the different program states having a different corresponding set of rules that control interaction of the digital therapeutics program with a user;
• accessing, by the server system, a database of pharmaceutical data indicating cancer medications and effects of the cancer medications on multiple individuals, the database indicating (i) incidence rates at which the effects are experienced by individuals who have taken the cancer medications and (ii) intensity measures indicating the intensity of the effects;
• accessing, by the server system, mapping data that indicates predetermined relationships between the effects of the cancer medications and different programs of the digital therapeutics programs;
• evaluating, by the server system, applicability of the respective digital therapeutics programs to the first user based on records for the first user that indicate (i) cancer medications currently or previously used by the first user and (ii) current physiological data for the first user, the evaluating comprising:
• identifying, by the server system and based on the records for the first user, cancer medications currently or previously used by the first user;
• determining, by the server system, a relevance score for each of the digital therapeutics programs based on values that the mapping data specifies for cancer medications currently or previously used by the first user, the relevance scores being further based on (i) the current physiological data for the first user and (ii) the incidence rates and the intensity measures indicated by the database of pharmaceutical data;
• and
• selecting, by the server system, one or more digital therapeutics programs based on the relevance scores;
• automatically varying, by the server system, treatment of the first user by altering the user-specific set of program states of the plurality of digital therapeutics programs to assign an updated user-specific set of program states for the first user and alter the digital therapeutics interventions provided to the first user,
• wherein the server system enforces interdependence of the digital therapeutics programs by altering the program states for the first user for at least some of the digital therapeutics programs based on stored data indicating the program states of one or more of the other digital therapeutics programs for the first user, and
• wherein the server system adjusts the set of program states for the first user to increase the level of intensity of the one or more digital therapeutics programs selected based on the relevance scores;
• generating, by the server system, second individualized application content for the first user by applying, for each of the active digital therapeutics programs, the set of rules corresponding to the updated program state for the digital therapeutics program;
• and
• distributing, by the server system and to the first device, the second individualized application content generated for the first user according to the updated user-specific set of program states.