A monoclonal antibody and a method of use for the treatment of lupus

A method for treating lupus in a subject comprising administering an anti-CD6 monoclonal antibody (T1h) that binds to domain 1 (D1) of CD6 without interfering with ALCAM binding to CD6, wherein the anti-CD6 monoclonal antibody comprises amino acid sequences of SEQ ID NO:

• 1 and SEQ ID NO:
• 2, and wherein the anti-CD6 monoclonal antibody is in a therapeutically effective amount to reduce the symptoms of lupus in the treated subject.

A method to reduce activation of T-cells in a subject patient with an elevated level of anti-nuclear antibodies (ANA) and/or anti-double-stranded DNA (dsDNA) antibodies, the method comprising administering to the subject a therapeutically effective amount of an anti-CD6 monoclonal antibody, wherein the anti-CD6 monoclonal antibody comprises amino acid sequences of SEQ ID NO:

• 1 and SEQ ID NO:
• 2.

Use of an anti-CD6 monoclonal antibody in the manufacture of medicament useful for the treatment of lupus, wherein the wherein the anti-CD6 monoclonal antibody comprises amino acid sequences of SEQ ID NO:

• 1 and SEQ ID NO:
• 2.