Immune-stimulating peptides and checkpoint inhibitors, and uses thereof for treating cancer
AssigneeIntendet Services, LLC
InventorsBrett P. GIROIR, Clifford H. KERN, III, Carola LEUSCHNER
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Abstract
Presented herein are immune-stimulating peptides and uses thereof for treating cancer. The immune-stimulating peptides can be used alone, or in combination with checkpoint inhibitors and other anti-cancer therapies. The immune-stimulating peptides can also be used for expanding T-cells in vitro or ex vivo, which expanded T-cells can then be used for adoptive cell therapy.
Claims46
A composition comprising (i) an immune-stimulating peptide and (ii) a checkpoint inhibitor.
The composition of any one of claims 1 to 9, wherein the checkpoint inhibitor is a chimeric, humanized or human monoclonal antibody.
A composition comprising an (i) immune-stimulating peptide and (ii) a checkpoint inhibitor wherein the immune-stimulating peptide comprises or consists of an amino acid sequence selected from YAGF, YAGW, YAibGF, YAibGFM. ACYGGGACG, ACYGGFACG, ACYGGBipACG, ACYGGDipACG, ACYGGAthACG, ACYGGDabACG, ACYGGDapACG and ACYGGNalACG.
A method of treating a cancer in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an immune-stimulating peptide and a therapeutically effective amount of a checkpoint inhibitor.
Dependencies are inferred from the claim text.