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US 2019/0241656 A1Published application
Combination of anti cd19 antibody with a bcl-2 inhibitor and uses thereof
AssigneeMorphosys AG
InventorsJan Endell, Konstantin Petropoulos, Peter Kelemen, Ranier Boxhammer, Markus Rückert
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Abstract
The present disclosure describes a pharmaceutical combination of an anti-CD19 antibody and a BCL-2 inhibitor for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and/or acute lymphoblastic leukemia.
Claims20
A combination comprising an antibody specific for CD19 wherein said antibody comprises an HCDR1 region comprising sequence SYVMH (SEQ ID NO:
- 1), an HCDR2 region comprising sequence NPYNDG (SEQ ID NO:
- 2), an HCDR3 region comprising sequence GTYYYGTRVFDY (SEQ ID NO:
- 3), an LCDR1 region comprising sequence RSSKSLQNVNGNTYLY (SEQ ID NO:
- 4), an LCDR2 region comprising sequence RMSNLNS (SEQ ID NO:
- 5), and an LCDR3 region comprising sequence MQHLEYPIT (SEQ ID NO:
- 6) and venetoclax for use in the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and/or acute lymphoblastic leukemia.
3 more elements
(canceled)
Dependencies are inferred from the claim text.