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US 2019/0241653 A1Published application
Humanized antibodies transmigrating the blood-brain barrier and uses thereof
AssigneeNational Research Council of Canada
InventorsDanica Stanimirovic, Kristin Kemmerich, Yves Durocher, Traian Sulea
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Abstract
The present invention relates to antibodies and fragments thereof derived by humanization of an existing antibody, and methods of making them. The humanized antibodies of the present invention show enhanced binding to the brain endothelial antigen, improved transmigration across the blood-brain barrier, and increased thermal stability relative to the parent non-humanized antibody.
Claims14
An isolated or purified antibody or fragment thereof, comprising the sequence
- X1VQLVESGGGLVQPGGSLRLSCAASGFKITHYTMGWX2RQAPGKX3X4EX5VSRITWG GDNTFYSNSVKGRFTISRDNSKNTX6YLQMNSLRAEDTAVYYCAAGSTSTATPLRVDY WGQGTLVTVSS (SEQ ID NO:9), where X1=D or E, X2=F or V, X3=E or G, X4=R or L, X5=F or W, X6=L or V.
Dependencies are inferred from the claim text.