Designer osteogenic proteins

A composition comprising a BMP comprising an amino sequence having at least 90% sequence identity with SEQ ID NO:

• 71 and a pharmaceutically acceptable carrier, wherein said amino acid sequence encodes a BMP having resistance to Noggin at a Noggin concentration of at least 4-fold higher than a BMP-GER-NR concentration and having osteogenic activity, as measured by an in vitro alkaline phosphatase assay.

A BMP comprising an amino sequence having at least 90% sequence identity with SEQ ID NO:

• 71, wherein said amino acid sequence encodes a BMP that is resistant to Noggin at a Noggin concentration of at least 4-fold higher than a BMP-GER-NR concentration and has osteogenic activity, as measured by an alkaline phosphatase assay.

A polynucleic acid encoding a BMP comprising amino acid sequence SEQ ID NO:

• 71.

A kit comprising a BMP of SEQ ID NO:

• 71;
• an applicator;
• and an instructional material setting forth information for the use of the kit to treat or prevent bone loss.

A BMP comprising an amino sequence having at least 90% sequence identity with SEQ ID NO:

• 37, wherein said amino acid sequence encodes a BMP having osteogenic activity as measured by an in vitro alkaline phosphatase assay.