Gene therapy for diabetic neuropathy using an hgf isoform
AssigneeViroMed Co., Ltd.
InventorsJong Mook KIM, Jae Gyun JEONG
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Abstract
The present invention relates to a pharmaceutical composition for the prevention or treatment of diabetic neuropathy, wherein the pharmaceutical composition comprises, as active ingredients, different types of isoforms of HGF or a polynucleotide encoding the isoforms. The present invention is the first invention demonstrating that diabetic neuropathy can be prevented and treated using different types of isoforms of HGF. According to the present invention, it is possible to very effectively treat diabetic neuropathy.
Claims2
A method for treating a human subject having painful diabetic peripheral neuropathy, the method comprising:
- intramuscularly administering to an affected limb of the human subject in need thereof a pCK-HGF-X7 DNA construct at a dose of 8 mg, equally divided into a plurality of injections and plurality of visits,
- wherein the pCK-HGF-X7 DNA construct comprises the nucleotide sequence as set forth in SEQ ID NO:
- 13, and
- wherein each of the plurality of injections is performed with 0.25 mg of the pCK-HGF-X7 DNA construct.
Dependencies are inferred from the claim text.