Chimeric proteins for inducing immunity towards infection with S. aureus
AssigneeEvaxion Biotech ApS
InventorsNiels Iversen Møller, Andreas Holm Mattsson, Jens Kringelum
Life of this patent
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Abstract
Disclosed is chimeric polypeptides derived from S. aureus proteins having SEQ ID NOs: 1-9 and 139-146. The chimeric polypeptides are useful as immunogens for providing protective immunity against S. aureus infection. Also disclosed are compositions, methods of treatment and prophylaxis, nucleic acids and vectors comprising the nucleic acids.
Claims147
A chimeric polypeptide comprising at least 2 non-identical amino acid sequences, where each of said at least 2 non-identical amino acid sequences consists of
- any one of SEQ ID NOs:
- 21, 23, 26, 27, 30, 33, 34, 38, and 40 wherein 0, 1, 2, or 3 amino acid residues can be substituted, or
- any one of SEQ ID NOs:
- 22, 24, 25, 28, 29, 31, 32, 35, 36, 37, and 39 wherein 0, 1, 2, or 3 amino acid residues can be substituted.
A chimeric polypeptide comprising formula I
- a1-A1-L-A2-a1 (I)
- wherein
- A1 is selected from the group consisting of
- an amino acid sequence constituted by at least or exactly 5 contiguous amino acid residues present in any one of SEQ ID Nos:
- 1-9 and 139-146, and
- an amino acid sequence with at least 80% sequence identity with an amino acid sequence constituted by at least or exactly 5 contiguous amino acid residues present in any one of SEQ ID Nos:
- 1-9 and 139-146,
- A2 is selected from the group consisting of
- an amino acid sequence constituted by at least or exactly 5 contiguous amino acid residues present in any one of SEQ ID Nos:
- 1-9 and 139-146, and
- an amino acid sequence with at least 80% sequence identity with an amino acid sequence constituted by at least or exactly 5 contiguous amino acid residues present in any one of SEQ ID Nos:
- 1-9 and 139-146,
- L is an optional amino acid sequence,
- a1 is an optional amino acid sequence, and
- b1 is an optional amino acid sequence.
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Dependencies are inferred from the claim text.