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US 2019/0241616 A1Published application
Angiotensin (1-7) analogs and methods relating thereto
AssigneesWake Forest University Health Sciences, Tensive Controls, Inc.
InventorsPATRICIA GALLAGHER, ANN TALLANT, DANIEL YOHANNES, KENNETH A. GRUBER
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Abstract
Angiotensin (1-7) analogs are provided. Also provided are methods of making such analogs methods for using analogs as therapeutic compositions such as, for example, treatment cancer.
Claims32
A peptide comprising the formula R1-Z-R9-Y1, wherein:
- R1 is norleucine (Nle), leucine (L), alanine (A), norvaline (Nva), azidohomoalanine (Aha), or 2-Aminobutyric acid (Abu);
- Z is an amino acid sequence having at least 85% identity to SEQ ID NO:1, wherein in Z has the formula R2-R3-R4-R5-R6-R7-R8;
- R9 is lysine (K), ornithine (Orn), 2,3-diaminopropionic acid (Dap), 2,4-diaminobutyric acid (Dab), or N-methyl lysine (NMe-K);
- and
- Y1 is absent or is a single amino acid extension or a two amino acid extension attached to R9;
- wherein R1-Z-R9 has a cyclic structure, wherein R1 or R2 is connected to R9.
3 more elements
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Dependencies are inferred from the claim text.