Cyclic tetrapeptide stereoisomers
AssigneeUniversity of Kansas
InventorsJane V. Aldrich, S P Sanjeewa Nilendra Senadheera
Life of this patent
Estimating the term…
Abstract
Cyclic tetrapeptide stereochemical isomers of CJ-15,208, pharmaceutical compositions from such cyclic tetrapeptides, and methods of using such pharmaceutical compositions. The cyclic tetrapeptide compounds and pharmaceutical compositions disclosed herein are potent analgesics active in several pain models with generally minimal tolerance and reduced likelihood to induce addiction relative to other known opiates.
Claims18
A method for treating and/or preventing depression and/or anxiety, comprising administering to a subject a therapeutically effective amount of a pharmaceutical composition comprising:
- a therapeutically effective amount of a cyclic tetrapeptide comprising a structure of Formula 1 with an amino acid sequence of cyclo[Phe-Pro-Phe-Trp] (SEQ ID NO:
- 1), or a derivative thereof, wherein the cyclic tetrapeptide comprises an amino acid configuration selected from the group consisting of [LDLD], [LDDL], [DDLL], [DDDL], [DDLD], [LLLL], [LLDL], [DLLL], [DLDL], [LLLD], [LLDD], [DLDD], and [DLLD], and wherein amino acid configuration of the cyclic tetrapeptide does not comprise [LDLL];
- and
- a pharmaceutically acceptable excipient or carrier.
A method for treating and/or preventing depression, comprising administering to a subject a therapeutically effective amount of a pharmaceutical composition comprising:
- a therapeutically effective amount of a cyclic tetrapeptide comprising a structure of Formula 1 with an amino acid sequence of cyclo[Phe-Pro-Phe-Trp] (SEQ ID NO:
- 1), or a derivative thereof, wherein the cyclic tetrapeptide comprises an amino acid configuration selected from the group consisting of [LDLD], [LDDL], [DDLL], [DDDL], [DDLD], [LLLL], [LLDL], [DLLL], [DLDL], [LLLD], [LLDD], [DLDD], and [DLLD], and wherein amino acid configuration of the cyclic tetrapeptide does not comprise [LDLL];
- and
- a pharmaceutically acceptable excipient or carrier.
A method for treating and/or preventing anxiety, comprising administering to a subject a therapeutically effective amount of a pharmaceutical composition comprising:
- a therapeutically effective amount of a cyclic tetrapeptide comprising a structure of Formula 1 with an amino acid sequence of cyclo[Phe-Pro-Phe-Trp] (SEQ ID NO:
- 1), or a derivative thereof, wherein the cyclic tetrapeptide comprises an amino acid configuration selected from the group consisting of [LDLD], [LDDL], [DDLL], [DDDL], [DDLD], [LLLL], [LLDL], [DLLL], [DLDL], [LLLD], [LLDD], [DLDD], and [DLLD], and wherein amino acid configuration of the cyclic tetrapeptide does not comprise [LDLL];
- and
- a pharmaceutically acceptable excipient or carrier.
Dependencies are inferred from the claim text.