Cyclohexene compounds and use thereof
AssigneeGuangzhou Henovcom Bioscience Co., Ltd.
InventorsJiancun Zhang, Kun Wang, Yan Liu, Deyao Li
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AssigneeGuangzhou Henovcom Bioscience Co., Ltd.
InventorsJiancun Zhang, Kun Wang, Yan Liu, Deyao Li
Estimating the term…
A cyclohexene compound and use thereof, which relates to the technical field of pharmaceutical chemistry is provided. The cyclohexene compound is the cyclohexene compound having a structural formula I or a pharmaceutically acceptable salt, an ester group prodrug or a stereoisomer thereof. It is verified by activity assay for influenza NA that the cyclohexene compound has a great inhibiting activity against both wild-typed and drug-resistant influenza viruses, and the inhibiting activity IC50 of some compounds against wild-typed and drug-resistant influenza viruses is lower than 5 nM, showing significant inhibiting effect on influenza viruses. This shows that the cyclohexene compound or a pharmaceutically acceptable salt or a stereoisomer thereof has superior application prospect on preparing anti-influenza drugs, thereby providing a new drug choice for treating influenza clinically.
1-9. (canceled)
A cyclohexene compound having a structural formula I or a pharmaceutically acceptable salt, an ester prodrug or a stereoisomer thereof:
Dependencies are inferred from the claim text.