Augmentation of Abscopal Effect of Cryotherapy and other Tumor Cell Death by Anti-angiogenic and Anti-tumor Vaccination

Abstract

Disclosed are means, methods, and compositions, useful for augmenting immune response to tumor cell death occurring in the body, wherein the tumor cell death acts as a source of antigens to stimulate an anti-cancer immune response. In one embodiment of the invention cryosurgery is performed in a manner to facilitate immune mediated killing of distant tumors, in effect causing an abscopal reaction, the amplification of the abscopal reaction is performed by preimmunization with antigen compositions generated to target tumor endothelium. In another embodiment the invention teaches the amplification of abscopal effect by preimmunizing with placental and/or tumor antigens prior to induction of necrotic cell death through means such as cryoablation, hyperthermia, radiation therapy, radiation therapy and intravenous vitamin C, and chemotherapy.

Dependencies are inferred from the claim text.