US 2019/0233541 A1Published application

Human antibody against aggrecanase-type adamts species for therapeutics of aggrecanase-related diseases

AssigneesGeneFrontier Corporation, Keio University

InventorsAkira MIYAKOSHI, Mikiko NAKAMURA, Kanehisa KOJOH, Satsuki MOCHIZUKI, Yasunori OKADA

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Abstract

The present invention provides an antibody that specifically binds to human aggrecanase, and inhibits enzymatic activity of the human aggrecanase. In one embodiment, aggrecanase is ADAMTS4. In one embodiment, the antibody recognizes a particular epitope in human ADAMTS4, and inhibits not only aggrecanase activity of human ADAMTS4 but also aggrecanase activity of human ADAMTS5. In addition, the present invention also provides use of said antibody in the prophylaxis or treatment of the progression of arthritis.

Claims12

Dependent claims

1-23. (canceled)

Dependencies are inferred from the claim text.

Facts

Application: 16/153,413Filed 5 Oct 2018
Priority: 15 Oct 2013
Published: 1 Aug 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification11 codes

C07K 16/40
Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies: against enzymes
A61P 19/02
Drugs for skeletal disorders: for joint disorders, e.g. arthritis, arthrosis
A61P 43/00
Drugs for specific purposes, not provided for in groups a61p1/00-a61p41/00
C07K 2317/21
Characterized by taxonomic origin: from primates, e.g. man

Family

Application61/891,087Us provisional application · filed 15 Oct 2013
Application15/029,823Continuation · filed 15 Apr 2016
Application16/153,413Continuation
US 10,640,573 B2Related patent
US 2016/0304622 A1Published application
US 2019/0233541 A1This patent

From the US filing history. Foreign family members aren’t listed.

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