Regulatory t cell mediator proteins and uses thereof
AssigneeTrustees of Dartmouth College
InventorsRandolph J. NOELLE, Li-Fan Lu, Sergio Quezada, David Gondek
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Abstract
The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon αCD3/αGITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.
Claims14
1-6. (canceled)
An isolated or recombinant human cell which has been engineered to express a human PD-L3 polypeptide or fragment, wherein said PD-L3 polypeptide or fragment promotes T cell proliferation and T cell activity.
A method of promoting T cell activity in a subject in need thereof comprising
- (i) isolating a cell from a human donor;
- (ii) engineering said isolated cell such that it expresses human PD-L3 polypeptide or fragment, wherein said PD-L3 polypeptide or fragment promotes T cell proliferation and T cell activity and
- (iii) introducing said engineered human cell into a human recipient who comprises a condition wherein increased T cell proliferation and activity is desired.
A method of promoting T cell activity in a subject in need thereof comprising
- (i) isolating one or more immune cells from a human donor;
- (ii) contacting said isolated one or more immune cells with a human PD-L3 polypeptide or fragment, wherein said PD-L3 polypeptide or fragment promotes T cell proliferation and T cell activity and
- (iii) introducing said human cells with have been contacted according to (ii) into a human recipient who comprises a condition wherein increased T cell proliferation and activity is desired.
Dependencies are inferred from the claim text.