US 2019/0170712 A1 · ANALYSIS DEVICE

Abstract

The detection of minute amounts of components that have been undetectable due to an influence of a mobile phase or reagents or the like added to the mobile phase is realized in LC-MS. At the outset, blank measurement is executed, and an m/z value MBG of a background signal derived from a mobile phase or the like is extracted on a mass spectrum obtained by the blank measurement (S2-S4). An analysis method is then created that executes scanning measurement in a plurality of divided m/z ranges in which the m/z value MBG of the background signal has been excluded from a predetermined m/z range. An LC/MS analysis of the target sample is executed according to the analysis method (S5-S6). When a total ion chromatogram (TIC) is created from data obtained by the LC/MS analysis, influence of the background signal hardly appears in the TIC, and the base line is lowered.

Claims10

Dependent claims

1-10. (canceled)

An analysis device comprising a mass spectrometer capable of obtaining a spectrum in a predetermined mass to charge ratio value range by executing an analysis according to an analysis method including analysis conditions, the analysis device being configured to detect, with the mass spectrometer, a component temporally separated by a chromatograph, the analysis device comprising:

a) a background information storage unit that stores a mass to charge ratio value of a background signal that appears in analysis;
and
b) an analysis method creation unit that creates, wherein one or a plurality of mass to charge ratio values or a mass to charge ratio value range are set as one of the analysis conditions, an analysis method in which one or a plurality of mass to charge ratio values or a mass to charge ratio value range obtained by removing the mass to charge ratio value stored in the background information storage unit from the set mass to charge ratio value or the set mass to charge ratio value range are used as an analysis object;
c) a chromatogram acquisition unit that creates a total ion chromatogram based on results obtained by an analysis of a target sample according to the analysis method;
and
d) a peak detector that detects a peak in which the proportion of a signal intensity on the total ion chromatogram to a signal intensity of a main peak on the chromatogram is equal to or larger than a predetermined threshold value.

3 more elements

An analysis device including a mass spectrometer capable of obtaining a spectrum in a predetermined mass to charge ratio value range, the analysis device being configured to detect, with the mass spectrometer, a component temporally separated by a chromatograph, the analysis device comprising:

a) an exclusion information setting unit that sets a mass to charge ratio value or a mass to charge ratio value range to be excluded from an analysis object;
and
b) an intensity value determination unit that removes the mass to charge ratio value or the mass to charge ratio value range set by the exclusion information setting unit, on a spectrum obtained by an analysis of a target sample, determines whether or not there is a peak having the signal intensity value that is larger than a predetermined threshold value with the mass to charge ratio value remaining in the mass to charge ratio value to determine a mass to charge ratio value at which a peak has the signal intensity value that is larger than the threshold value
c) a chromatogram creation unit that creates an extraction ion chromatogram at a mass to charge ratio value obtained in the intensity value determination unit using data obtained by an analysis of the target sample,
wherein the peak is detected with the extraction ion chromatogram.

2 more elements

Dependencies are inferred from the claim text.

Analysis device

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Analysis device

Life of this patent

Abstract

Claims10