Method for predicting response to breast cancer therapeutic agents and method of treatment of breast cancer

A method of treating triple negative breast cancer in a subject, said subject having a breast cancer comprising breast cancer cells that have been classified as basal-like subtype or another sub-type, said method comprising;

• testing the subject to determine the Basal Centroid classifier score of breast cancer cells of the subject;
• and
• administering a breast cancer treatment to the subject comprising an androgen receptor inhibitor, thereby treating the triple negative breast cancer in the subject;
• wherein the Basal Centroid classifier score is determined for the breast cancer cells of the subject from the expression by said cells of the set of intrinsic genes listed in Table 1;
• and
• wherein the breast cancer cells of the subject are characterized by a Basal Centroid classifier score of less than or equal to 0.9.

A method of treating triple negative breast cancer in a subject in raced of such treatment comprising:

• (a) providing a biological sample from the subject;
• (b) assaying the biological sample to determine whether the biological sample is classified as a basal-like subtype or another subtype, wherein the Basal Centroid classifier score of breast cancer cells is determined for the breast cancer cells of the subject from the expression by said cells of the set of intrinsic genes listed in Table 1 and wherein the breast cancer cells of the subject are characterized by a Basal Centroid classifier score of less than or equal to 0.9;
• and
• (c) if the biological sample is classified as the other than a basal-like subtype, administering a breast cancer treatment to the subject comprising an androgen receptor inhibitor, thereby treating the breast cancer in the subject.