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AssigneePersona Biomed, Inc.
InventorFernando Vidal-Vanaclocha
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A method of detecting prometastatic cancer activity in the liver of a patient suffering from colorectal cancer, as well as a method of diagnosing and treating colorectal cancer according to primary tumor location, based on divergent expression levels and functional classification of specific genes in tumor unaffected hepatic tissue. Specific genes include statistically significant ones of group 1 genes PRDX4, CRP, ID1, MT1E, TNFSF14, MRC1, ICAM1, IL18, IL10, TFN; group 2 genes NGF, EPHA1, ERBB2IP, SDC1, COL18A1, KNG1, ADH1B, CYP2E1; and group 3 genes HP, VTN, RPS27, RPL23, GAPDH, TXN, VEGFA, CEACAM1, IGF1, TGFB1, DDR2, NOS2, and BMP7. These genes are compared with corresponding genes of individuals free of colorectal cancer in magnitude, correlation patterns, clustering patterns, heatmaps and other comparative analyses to derive insight into the tumor microenvironment to detect the onset of tumor growth, which enables early treatment well before conventional clinical signs emerge via any type of imaging, for example. Instead of analyzing the specifically denoted genes in hepatic tissue, the method may be implemented utilizing protein signatures of gene products derived from the patient's blood serum or plasma, in which case, the protein signatures indicate expression levels of the specific genes involved from which the analyses may be performed.
A method of detecting metastatic cancer in a target patient having a colorectal tumor, said method comprising:
A method of detecting occult cancer in a target patient having a gastrointestinal disorder, said method comprising:
A method of diagnosing and treating a patient suspected of having a subclinical liver micrometastasis disease or subclinical liver metastasis with a targeted gene therapy comprising, said method comprising:
A method of detecting anatomical location of an occult CRC tumor in a patient without clinical evidence of CRC, said method comprising;
A method of diagnosing and treating a patient with CRC comprising (a) obtaining from the patient a sample of hepatic tissue or blood serum/plasma, (b) in said sample, measuring expression levels of liver prometastatic genes or proteins to identify abnormal genes or gene products (i.e., protein production) being overexpressed and/or underexpressed, and (c) treating the patient with a liver metastasis-specific therapy that targets (i) said abnormal genes, (ii) specific gene expression products or receptors of said abnormal genes and/or (iii) associated signaling pathways of said abnormal genes.
A method of detecting liver metastasis or risk thereof in a patient afflicted with CRC, obesity, gallstones, or other disease increasing CRC risk, said method comprising the steps of (a) obtaining from the patient a sample of blood serum or plasma to be examined;
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