Loading patent…
AssigneesFundació Institut de Recerca Biomèdica (IRB Barcelona), Institució Catalana De Recerca I Estudis AvançAts
InventorsRoger GOMIS, Maria Tarragona, Anna Arnal, Milica Pavlovic
Estimating the term…
The present invention relates to a method for the diagnosis or the prognosis of metastasis in breast cancer which comprises determining if the c-MAF gene is amplified in a primary tumor sample. Likewise, the invention also relates to a method for the diagnosis or the prognosis of metastasis in ER− breast cancer, as well as to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which comprise determining the c-MAF gene expression level. Finally, the invention relates to the use of a c-MAF inhibitor as therapeutic target for treating the ER− breast cancer metastasis.
1-32. (canceled)
A method for the treatment of bone metastasis in a subject suffering breast cancer with an elevated c-MAF expression level, copy number or amplification in a tumor tissue sample with respect to a control sample comprising administering an agent capable of avoiding, treating, or preventing bone degradation to said subject suffering breast cancer, wherein said subject has been determined to have an elevated c-MAF expression level, copy number or amplification.
A method for the treatment of bone metastasis in a subject suffering breast cancer comprising:
Dependencies are inferred from the claim text.