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US 2019/0169690 A1Published application
Methods and compositions for diagnosis of alzheimer's disease
AssigneeRosetta Genomics Ltd.
InventorYaron Goren
Life of this patent
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Abstract
The invention provides a method of diagnosing Alzheimer's disease (AD) in a subject by determining the level of expression of one or more miRNAs molecules associated with AD, as well as various nucleic acid molecules relating thereto or derived thereof.
Claims22
A method of diagnosing Alzheimer's disease (AD) in a subject, the method comprising:
- obtaining a biological sample from a subject;
- determining an expression profile in said sample of a nucleic acid sequence selected from the group consisting of SEQ ID NOS:
- 1-67;
- a fragment thereof or a sequence having at least about 80% identity thereto;
- and comparing said expression profile to a reference expression profile wherein a difference in the level of expression profile in at least one or more nucleic acid sequence in said biological sample compared to said reference expression profile is diagnostic for AD.
2 more elements
A kit for assessing AD in a subject, said kit comprising a probe comprising a nucleic acid sequence that is complementary to a sequence selected from the group consisting of SEQ ID NOS:
- 1-67;
- a fragment thereof and a sequence having at least about 80% identity thereto.
Dependencies are inferred from the claim text.