Antifungal Plant Proteins, Peptides, and Methods of Use
AssigneeDonald Danforth Plant Science Center
InventorDilip Shah
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AssigneeDonald Danforth Plant Science Center
InventorDilip Shah
Estimating the term…
Provided are transgenic plants expressing MtDef5 antifungal proteins and peptides exhibiting high levels of resistance to susceptible fungi. Such transgenic plants contain a recombinant DNA construct comprising a natural or heterologous signal peptide sequence operably linked to a nucleic acid sequence encoding these molecules. Also provided are methods of producing such plants, methods of protecting plants against susceptible fungal infection and damage, as well as compositions that can be applied to the locus of plants, comprising microorganisms expressing these molecules, or these molecules themselves, as well as pharmaceutical compositions containing these molecules. Human and veterinary therapeutic use of MtDef5 antifungal proteins and peptides to treat susceptible fungal infections are also encompassed by the invention.
An isolated, purified protein or peptide, comprising an amino acid sequence having at least 90% sequence identity to an amino acid sequence selected from the group consisting of amino acid sequences shown in SEQ ID NOs:1, 3-9, 16-22, and 49-64.
A transgenic plant, cells of which contain a protein or peptide comprising an amino acid sequence having at least 90% sequence identity to an amino acid sequence selected from the group consisting of amino acid sequences shown in SEQ ID NOs:1, 3-9, 16-22, and 49-64.
A composition, comprising a protein or peptide comprising an amino acid sequence having at least 90% sequence identity to an amino acid sequence selected from the group consisting of amino acid sequences shown in SEQ ID NOs:1, 3-9, 16-22, and 49-64, and any combination thereof.
A method of preventing, treating, controlling, combating, reducing, or inhibiting damage to a plant susceptible to damage from a species of fungus selected from the group consisting of an Alternaria sp., an Ascochyta sp., an Aspergillus sp., a Botrytis sp.;
Dependencies are inferred from the claim text.