Methods and compositions to prevent microbial infection
AssigneeBioPlx, Inc.
InventorsTimothy W. Starzl, Todd D. Turner, Ravi S. V. Starzl
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Abstract
Methods and compositions are provided for durably influencing microbiological ecosystems (microbiomes) in a subject in order to prevent infection and reduce recurrence of infection by microorganisms. In some embodiments, compositions and methods are provided for the creation and use of molecularly-modified bacterial strains with the potential to prevent a variety of microorganism infections.
Claims108
A synthetic microorganism, comprising a recombinant nucleotide comprising
- at least one kill switch molecular modification comprising
- a first cell death gene operatively associated with
- a first regulatory region comprising an inducible first promoter, wherein
- the first inducible promoter exhibits conditionally high level gene expression of the recombinant nucleotide in response to exposure to blood, serum, or plasma of at least three fold increase of basal productivity.
(canceled)
A method for eliminating and preventing the recurrence of a undesirable microorganism in a subject hosting a microbiome, comprising:
- a. decolonizing the host microbiome;
- and
- b. durably replacing the undesirable microorganism by administering to the subject a synthetic microorganism comprising at least one element imparting a non-native attribute, wherein the synthetic microorganism is capable of durably integrating to the host microbiome, and occupying the same niche in the host microbiome as the undesirable microorganism.
Dependencies are inferred from the claim text.