Targeted/immunomodulatory fusion proteins in combination with additional therapeutic agents and methods for making same
AssigneeBiocon Limited
InventorsNAGARAJ GOVINDAPPA, SREESHA P. SRINIVASA, USHA BUGHANI, RESHMI NAIR
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Abstract
The present invention provides for a composition and a method for treating a subject afflicted with a cancer, wherein the composition comprises therapeutically effective amounts of: (a) an anti-Programmed Death-Ligand 1 (PD-L1) antibody and (b) a targeted/immunomodulatory fusion protein comprising at least one tumor targeting moiety and at least one immunomodulatory moiety that counteracts the immune tolerance of cancer cells.
Claims22
A composition combining multiple cancer therapeutic agents, the composition comprising an anti-PD-L1 antibody and a chimeric targeted/immunomodulatory fusion polypeptide comprising at least one tumor targeting moiety to target a cancer cell and at least one immunomodulating moiety that counteracts immune tolerance of cancer cell.
A method for immunotherapy of a subject afflicted with cancer, which method comprises administering to the subject a composition comprising a therapeutically effective amount of an anti-PD-L1 antibody and a chimeric targeted/immunomodulatory fusion polypeptide comprising an immunomodulatory moiety that binds transforming growth factor beta (TGF-β) and a tumor targeting moiety that binds to EGFR1.
A kit for treating cancer comprising a combination of an anti-PD-L1 antibody and a chimeric polypeptide comprising an immunomodulatory moiety that binds to and traps transforming growth factor beta (TGF-β) and a tumor targeting moiety that is an antibody that binds to EGFR1.
A method for increasing IFNγ release and TGF-β1 trapping in cancer cells, the method comprising introducing to the cancer cells a combination of a therapeutically effective amount of an anti-PD-L1 antibody and a chimeric targeted/immunomodulatory fusion polypeptide comprising an immunomodulatory moiety that binds transforming growth factor beta (TGF-β) and a tumor targeting moiety that binds to EGFR1.
Dependencies are inferred from the claim text.