Monoclonal antibody specific for gamma-glutamyl-l-epsilon-lysine for the monitoring of apoptosis
AssigneeAdvanced Biodesign
InventorsIsmail CEYLAN, Gerry QUASH, Mileidys PEREZ-ALEA, Guillaume MARTIN
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Abstract
The present invention concerns an ex vivo method for the monitoring of apoptosis which is based on the detection of free gamma-glutamyl-L-epsilon-Lysine (GGEL) in a biological sample of a subject with a monoclonal antibody specific to GGEL. The invention also relates to the monoclonal antibody specific to GGEL, as well as to diagnostic kits containing such a ligand.
Claims16
An isolated monoclonal antibody specific for gamma-glutamyl-L-epsilon-Lysine (GGEL) which comprises CDR-H1 of sequence SEQ ID NO:3, CDR-H2 of sequence SEQ ID NO:4, CDR-H3 of sequence SEQ ID NO:5, CDR-L1 of sequence SEQ ID NO:6, CDR-L2 of sequence SEQ ID NO:7, and CDR-L3 of sequence SEQ ID NO:8.
Dependencies are inferred from the claim text.