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AssigneeAmgen Research (Munich) GmbH
InventorsPeter Kufer, Tobias Raum, Roman Kischel, Ralf Lutterbüse, Patrick Hoffmann, Doris Rau, Susanne Mangold, Matthias Klinger, Evelyne Schaller, Susanne Hausmann, Petra Fluhr, Carola Steiger
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The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to prostate-specific membrane antigen (PSMA). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain anti-body molecule.
A bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human CD3epsilon (CD3ε) chain and non-chimpanzee primate-CD3ε chain, wherein the epitope is part of the amino acid sequence set forth in SEQ ID NO:
15-16. (canceled)
20-27. (canceled)
32-33. (canceled)
Dependencies are inferred from the claim text.