Humanized Anti-OX40 Antibodies and Uses Thereof

An antibody or antigen-binding fragment thereof, comprising:

• a humanized heavy chain variable region (VH) and a humanized light chain variable region (VL);
• wherein the VH comprises an amino acid sequence with the formula:
• HFW1-HCDR1-HFW2-HCDR2-HFW3-HCDR3-HFW4,
• wherein HFW 1 is SEQ ID NO:
• 6 or SEQ ID NO:
• 7, HCDR1 is SEQ ID NO:
• 8, HFW2 is SEQ ID NO:
• 9, SEQ ID NO:
• 10, SEQ ID NO:
• 11, SEQ ID NO:
• 12, or SEQ ID NO:
• 13, HCDR2 is SEQ ID NO:
• 14, SEQ ID NO:
• 15 or SEQ ID NO:
• 16, HFW3 is SEQ ID NO:
• 17, SEQ ID NO:
• 18, SEQ ID NO:
• 19, SEQ ID NO:
• 20, SEQ ID NO:
• 21, SEQ ID NO:
• 22, SEQ ID NO:
• 23, or SEQ ID NO:
• 24, HCDR3 is SEQ ID NO:
• 25, SEQ ID NO:
• 26, or SEQ ID NO:
• 27, and HFW4 is SEQ ID NO:
• 28;
• wherein the VL comprises the amino acid sequence SEQ ID NO:
• 29 or SEQ ID NO:
• 32;
• and
• wherein the antibody or antigen-binding fragment thereof can specifically bind to human OX40.