Compositions and methods for modulating an immune response
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsRichard S. Blumberg, Kristi Baker, Timo Rath
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Abstract
Described herein are compositions for increasing IL-12 production comprising IgG or a fragment thereof or a variant thereof and uses of said compositions for treating cancer and infectious diseases. Also described herein are compositions for decreasing IL-12 production comprising an agent that inhibits signaling mediated by interaction between FcRn and IgG and uses of said compositions for treating autoimmune diseases. Further described herein are methods for assessing efficacy of treatment by monitoring levels of various cytokines in the subject.
Claims21
A composition for increasing IL-12 production, the composition comprising immunoglobulin G (IgG) or a variant thereof or a fragment thereof.
The composition of 7, wherein the antigen is a protein or a proteomimetic thereof, a peptide or a peptidomimetic thereof, a lipid or a combination thereof.
A composition for decreasing IL-12 production, the composition comprising an agent that inhibits signaling mediated by interaction between FcRn and IgG.
A method for modulating the interaction between FcRn and IgG comprising contacting a cell with an agent that binds FcRn and/or IgG and modulates binding of FcRn to IgG.
-53. (canceled)
Dependencies are inferred from the claim text.