Compositions and methods of treating ocular diseases
AssigneeNovelmed Therapeutics, Inc.
InventorRekha Bansal
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Abstract
A method of treating a complement mediated ocular inflammation, hemorrhaging and fibrosis, and the pathological consequences thereof, in a subject in need thereof, the method comprising of administering to the subject a therapeutically effective amount of an antibody which inhibits the alternative complement pathway, wherein the antibody administered is effective for inhibiting complement mediated ocular inflammation, hemorrhaging and fibrosis, and the pathological consequences thereof.
Claims18
1-79. (canceled)
A method of treating ocular pathologies associated with fibrosis and hemorrhage within and around the macula of a subject in need thereof, the method comprising:
- administering to the subject a therapeutically effective amount of an anti-Bb antibody or antigen binding fragment thereof that binds to a component of alternative pathway and inhibits alternative pathway activation, wherein the ant-Bb antibody or antigen binding fragment thereof includes a light chain variable domain including 3CDRs of SEQ ID NO:
- 36 and a heavy chain variable domain including 3CDRs of SEQ ID NO:
- 79.
A method of treating ocular disorders in a subject in need thereof, comprising administering to the subject undergoing anti-VEGF, anti-PDGF treatment a therapeutically effective amount of an anti-Bb antibody or antigen binding fragment thereof that binds to a component of alternative pathway and inhibits alternative pathway activation, wherein the anti-Bb antibody or antigen binding fragment thereof includes a light chain variable domain including 3CDRs of SEQ ID NO:
- 36 and a heavy chain variable domain including 3CDRs of SEQ ID NO:
- 79.
Dependencies are inferred from the claim text.