Compositions and methods for inhibiting endogenous immunoglobulin genes and producing transgenic human idiotype antibodies
AssigneeOpen Monoclonal Technology, Inc.
InventorRoland BUELOW
Life of this patent
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Abstract
The invention relates to transgenic animals lacking endogenous Ig and capable of producing transgenic antibodies, as well as methods of making the same. The invention further relates to Methods for producing transgenic antibodies in such animals, and transgenic antibodies so produced.
Claims31
1-34. (canceled)
A chimeric monoclonal antibody comprising a non-human IgG constant region, a light chain and/or heavy chain, and a human idiotype, and wherein the non-human constant region comprises a rat IgG CH2 and CH3 domain.
A polyclonal antiserum comprising a plurality of chimeric antibodies, wherein the individual chimeric antibodies comprise a non-human IgG constant region, a heavy chain and/or light chain, and a human idiotype, and wherein the non-human constant region comprises a rat IgG CH2 and CH3 domain.
A diversified repertoire of chimeric immunoglobulins, wherein the individual chimeric immunoglobulins comprise a non-human IgG constant region, a heavy chain and/or light chain, and a human idiotype, and wherein the non-human constant region comprises a rat IgG CH2 and CH3 domain.
A nucleic acid encoding a chimeric monoclonal antibody comprising a non-human IgG constant region, a heavy chain and/or light chain, and a human idiotype, and wherein the non-human constant region comprises a rat IgG CH2 and CH3 domain.
Dependencies are inferred from the claim text.