Compositions And Methods For Enhancing Visual Function
AssigneeThe Regents of the University of California
InventorEhud Y. ISACOFF
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Abstract
The present disclosure provides a method of restoring or enhancing visual function in an individual, the method comprising administering to the individual a nucleic acid comprising a nucleotide sequence encoding one or more of a medium wavelength cone opsin (MW-opsin), a long wavelength cone opsin (LW-opsin), and a short wavelength cone opsin (SW-opsin). One or more of the MW-opsin, LW-opsin, and SW-opsin is expressed in a retinal cell in the individual, thereby restoring or enhancing visual function.
Claims25
-54. (canceled)
A method of restoring or enhancing visual function in an individual, the method comprising administering to the individual at least one nucleic acid comprising a nucleotide sequence encoding a medium wavelength opsin (MW-opsin) and/or a long wavelength opsin (LW-opsin) and/or a short wavelength opsin (SW-opsin), wherein said administering provides for expression of the MW-opsin and/or the LW-opsin and/or the SW-opsin in a retinal cell in the individual and restoration or enhancement of visual function, wherein the retinal cell is a retinal ganglion cell, an amacrine cell, a horizontal cell, or a bipolar cell.
Dependencies are inferred from the claim text.