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US 2019/0169241 A1Published application
Kif13b-derived peptide and method of inhibiting angiogenesis
AssigneeThe Board of Trustees of the University of Illinois
InventorsKaori YAMADA, Asrar MALIK
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Abstract
A construct composed of a Kinesin-derived Angiogenesis Inhibitor peptide and one or more carrier moieties and/or stabilizing moieties is provided as are methods for inhibiting angiogenesis and treating a disease or condition characterized by excessive vascularity.
Claims13
A construct comprising a 16 to 65 amino acid peptide comprising the amino acid sequence Thr-Xaa1-Xaa2-Xaa3-Glu-Arg-Xaa4-Xaa5-Leu-Ile-Xaa6-Arg-Xaa7-Xaa8-Val-Xaa9 (SEQ ID NO:1) operably linked to
- (a) one or more carrier moieties,
- (b) one or more stabilizing moieties, or
- (c) a combination of (a) and (b),
- wherein Xaa1 is Pro, Ala or Glu;
- Xaa2 is Val, Ala or Ser;
- Xaa3 is Asp or Asn;
- Xaa4 is Leu or Val;
- Xaa5 is Phe or Tyr;
- Xaa6 is Leu or Val;
- Xaa7 is Val, Ala or Thr;
- Xaa8 is Thr or Ala;
- and Xaa9 is Gln or Arg.
9 more elements
Dependencies are inferred from the claim text.