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US 2019/0169232 A1Published application
C1q AND HMGB1 FUSION PROTEINS AND USES THEREOF
AssigneeThe Feinstein Institute for Medical Research
InventorBetty A. Diamond
Life of this patent
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Abstract
Fusion proteins of C1q peptides and HMBG1 A-box or HMBG1 B-box, or C1q peptides and DWESY peptide are provided, and methods of use thereof.
Claims18
A method of cross-linking LAIR-1 and RAGE comprising contacting the LAIR-1 and RAGE with a composition that binds to LAIR-1 and RAGE comprising a polypeptide.
A polypeptide comprising (i) a C1q dodecamer peptide, or a C1q nonamer peptide wherein the nonamer peptide comprises KGEQGEPGA (SEQ ID NO:5), and (ii) a HMBG1 A-box peptide or a HMBG1 B-box peptide.
14-26. (canceled)
30-48. (canceled)
Dependencies are inferred from the claim text.